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Regrowth of Neurons

by: Dr. Larry Sosna

Regrowth of neurons… also called Neuro-Regeneration is one of the most complicated

issues in the field of medical/science. The subject matter concerns the repair and

regrowth of nerve cells called neurons. The long body of the neuron is called the Axon.

This issue is divided into two imperative groups…. Peripheral Nervous System (PNS)

and the Central Nervous System (CNS) characterized by the brain and spinal cord.

When I took High School Biology the teacher made a clear and emphatic

statement. Central Nervous System neurons NEVER heal. He went on to state, that

Peripheral Neurons do heal but slowly. In Biology and Biochemistry at undergraduate

work in college both professors made the exact same statement my high school biology

teach made almost by rote. Never one to fully agree with such absolute matters in

science my questions were so penetrating and complex as to be unanswerable which

gained respect by one Professor and benign neglect from the second Professor

PNS has a method of regeneration to the injured neurons followed by the quick release

of white blood cells to fight infection. Schwann cells release neurotropic factors which

enhance regrowth of PNS neurons in several ways. The Schwann cells, prevent to

much cytotoxicity which is generally part of the healing process but illicit’s far to much

inflammation for regeneration to proceed normally. Schwann cells, also set up tubes

along side the damaged neuron. These tubes are even connected to the injured

degraded PNS neuron and a host of healing biochemicals are release by the tube to

stop neural degradation and provide healing repair to the affected injured neuron.

There are a host of outside interventions that can make this process go faster but I will

save them for Regeneration of the brain and spinal cord, which please remember is

still thought in many universities even taught to this day that CNS neurons cannot

Regeneration and Repair of the Central Nervous System (Brain and Spinal Cord. There

are two types of cells meant to serve and protect CNS neurons from injury. They are

called Astrocytes and Gllial cells. It may be hard to believe but there are many more

astrocytes in the brain then there are brain Neurons and there are some 15 to 18 billion

brain neurons. Normally, after injury to brain neurons…astrocytes support neurons by

providing antioxidant protection.

The Good the Bad and the Ugly

While the Astrocytes bring in many antioxidants to prevent free radical oxidative toxic

damage to the brain neurons…they also over-react and allow for too much inflammation

and cytotoxins from white blood cell production of Interleukin-2 and 6… this is called up-

regulation of immune cell activity. It can destroy brain neurons faster then the initial

injury to a brain or spinal neurons. This process

brings about even more inflammation to try and carry away all of the dead cells,

including neurons and astrocytes as well as white blood cell waste deposits.

Unfortunately the brain is limited in size and to much inflammation causes intracranial

pressure to the point where brain infarct is possible without making a surgical opening in

the cranium to release the pressure….that is the bad and the ugly.

How do we solve the above dire situation and bring about brain cell neuron

In some cases like bacterial or viral Encephalitis of the brain and spinal cord

many neurons can be killed or injured due to massive white blood cell

proliferation. The white blood cells kill the bacteria and virus that causes

Encephalitis but the situation is so dramatic that in order for the brain to survive

the infection killing neurons…the message which signals the white blood cells to

enter the brain becomes so up-regulated that cannot down-regulate to a normal

response thus further killing both infected neurons and the infected brain cells

both. Many people die from this berserk super up-regulated immune response

stuck on full throttle. It is a vicious repetitive cycle.

We can stop this deathly cycle by giving the patient large intravenous doses of

Gamma Globulin. Gamma Globulin consists of every type of antibody the human

body can make. Scientists are not exactly certain how and why this has such a

profound normalizing effect immunologically but it does. It is called Immuno-

modulation to the normal set point.

In both Stroke patients and infection based Encephalitis of the brain… Immuno-

Modulation to a normal set point is a must in order for neuron cell death to stop and for

Certain biochemical factors play a vital role to decrease astrocytes!  Cyclin Kinase

decreases astrocyte proliferation, increasing neuron function and recovery. Caffeic acid,

alpha- melanocyte stimulating hormone and cliostazol are all highly beneficial. They are

considered essential to a improved condition by reducing astrocyte production…this

treatment shows a decrease in neuron injury, the decrease in astrocyte high levels of

production is associated with a more positive and improved outcome moving toward

In 1984, I experienced a life/death illness called Herpetic Viral Encephalitis. It was

misdiagnosed my Manhattans most elite doctors…virtually always fatal, I lived and due

to the fact the death rate is so nearly complete I spent 3 years in bed and several more

in a wheel chair. There was no internet, no smart phones, just a nearly destroyed brain

with pain so blinding it felt as if two ice picks were being run through both eyes… and

trying to escape by pushing through the back of my skull. Luckily for me the feelers I

sent out daily… resulted in a call from Nobel prize winning doctor and scientist, Dr. Rita

Levi Montalcini who won the Nobel Prize for the discovery of Embryonic Fetal Nerve

Growth Factor in 1986. I was the first human to ever get shots of Fetal Nerve Growth

Factor in 1988 to grow back and regenerate my damaged brain neurons. Then this

magnificent woman became my mentor….I still live speaking to her shadow everyday as

she passed over at the age of almost 104.

Rita Levi-Montalcini’s discovery of a protein called ‘fetal nerve growth factor,”

which fosters the growth of nerve fibers and also plays a role in the brain and the immune

system, is one of the most important steps taken so far toward understanding how the

fantastically complex system of nerves is laid down and linked to the tissues in a developing

embryo. Her account of the adventures leading to this discovery, for which she won a Nobel

Prize in Physiology and Medicine in 1986, has a special contemporary interest. We now

know her discovery is how the brain grows all of it’s neurons when one is an embryo inside

one’s mothers womb until birth and sustains, protects and regenerates brain neurons if one

is fortunate to be born with a large amount of FNGF .  Thank goodness she was able to scale

it up through a deal with a large cutting edge biotechnology lab. in Montreal. They are the

ONLY Lab. in the world to this day that makes Dr. Rita’s original formulations.

We at AA,I are indeed incredibly fortunate to be able to have access to her formulations at

I combined her fetal nerve growth factors with very youthful blood levels of HGH (human

growth hormone…levels that would be normal for the average healthy 16 year old. Eighteen

months later, I was completely better in every way… brain regeneration wise… and in every

other health manner. The addition of HGH was my inspiration as it has been known for

many decades that it is HGH which mobilizes all of the fetal tissue growth factors such as

cardiac tissue growth factor…to do protein synthesis and thus regeneration of the heart

AND all other tissues contained within the human body. Without youthful blood levels of

HGH(say blood levels normal for a healthy 26 year old to 30 year old) and credible levels of

fetal nerve growth factor… regrowth of Neurons is unlikely in the extreme BUT with these

safe and effective blood levels of both Regrowth of every type of Neuron is probable in and

that brings amazing hope. The only Regrowth we cannot master yet is CNS spinal cord cut

in half…but the army medical scientists are getting very close.

Imagine how old we would all look, if we did not have adequate cell levels of

epithelial (skin tissue growth factor) to regenerate our SKIN? So, just like

hormones, as we age we lose our tissue growth factors…and if they cannot be

replaced to the optimal level from exogenous sources we will all be subject to

the ravages of age related illness.

Gratefully, here at AAI we have all critical tissue growth factors available to

you, our beloved family of clients.

Kindly, Larry Sosna PhD HHP

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