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Reversing Atherosclerosis and Cardiovascular Disease

Healthy senior couple over fresh fruits and vegetables background.

Healthy senior couple over fresh fruits and vegetables background.

by: Larry Sosna N.D. PhD HHP

The Medical establishment would have all of us believe that coronary heart disease is irreversible and must lead to

either the eventual so called heart attack due to clogged arteries; or to by-pass operations, stents, followed by

balloon angioplasty. They tell us with Statin drugs the patient will then be ok. The statistics paint a very different

picture. Two out of every three people who have had cardiac by-pass surgery will need it again within 10 years.

Ten out of ten cardiovascular patients who have had stent procedures will need them again within 6.4 years.

Clearly, even with massive doses of statin drugs the treatment protocol for cardiovascular patients in use today by

the medical establishment is a failure in the sense that it’s not a cure and the above protocol is an ongoing radical

process for the body to endure.

One need  look no further than the case of former President Bill Clinton who had Quadruple by-pass heart surgery,

stent after stent, balloon angioplasty again and again, massive statins and still he had advanced coronary artery

disease(CAD) until he finally discovered a natural, yet very scientific integrative treatment protocol which has

reversed his CAD.

In the 1960’s and 1970’s Nathan Pritikin M.D. developed a unique diet rich in massive amounts of fruits and

vegetables and very low in total calories and fats. Dr. Pritikin developed this protocol after he was diagnosed with

severe atherosclerosis of the coronary arteries. He was so convinced his protocol reversed CAD he left instructions

in his will that when he died he was to have a cardiologist examine the condition of his arteries. Meanwhile

thousands of his patients went off all medications and never had any more coronary artery problems. After Dr.

Pritikin died in 1987, his heart was dissected; the arteries were determined by cardiologists to be clean and in the

condition of a 25 year old.

In 1987, two years after Dr. Pritikin’s death, the Journal of the American Medical Association announced a study

that showed the reversal of atherosclerosis in the coronary arteries of humans who were on the Pritikin protocol as

administered at the Pritikin Longevity centers had been a success.1 Numerous subsequent studies confirmed Dr.

Pritikin was scientifically correct and the medical establishment’s position fatally flawed.2,3

Tens of millions of Americans needlessly perished because the medical establishment refuses to understand the

true causes of Coronary Artery Disease.

The over-promotion of “Statin” drugs has resulted in today’s cardiologists focusing on getting their patients’ total

cholesterol and LDL down to dangerously low levels. Pharmaceutical company advertising has made it appear as if

the only cause of CAD is excess LDL and cholesterol; however over a thousand scientific peer reviewed research

studies show this conclusion to be completely false…

Beginning in 1979, medical researcher scientists made discoveries which clearly indicated that CAD was the result

of the oxidation of LDL that results in the formation of blocked arteries and arterial damage.4,5   Thousands of peer

reviewed studies now reveal how oxidized LDL creates CAD from start to finish.

There are doctors who argue that CAD is all about inflammation and they are correct but what they failed to

realize is that oxidized cholesterol mainly LDL injures endothelial cells and causes this massive inflammation of the

coronary arteries.6-12

Oxidized LDL causes endothelial cells to secrete ultra-sticky adhesion molecules that allow white blood cells to

penetrate the inner lining of the artery. This is where initial fatty streaks congeal and atherosclerotic plaques

develop in thickening layers.13

Oxidized LDL turns on white blood cell gene expression that enable them to convert into foam cells, which results

in continuous accumulation of oxidized LDL and thick plaque in the coronary arteries.14

Oxidized LDL initiates an inflammatory process by causing foam cells to make molecules that attract

proinflammatory cells and cytotoxins that further inflame the artery linings.15

Oxidized LDL enhances the process whereby immune cells, foam cells, smooth muscle cells, and the lining of

coronary arteries called endothelial cells, degrade collagen, which leads to the rupture of the fibrous plaque. The

extreme heat from the inflammation can cause even small amounts of cholesterol to blow up 40 times their normal

size and clot up an entire coronary artery, thus recently the Harvard study group called this phenomenon Popcorn

Cholesterol. This finally explains why 53% of all fatal heart attacks occur in people with rather low cholesterol,

something until recently which has greatly confused cardiac medical researchers.16

Forty years ago coronary artery disease was the #1 cause of death in America roughly 600,000 people died each

year from CAD. Today despite doctors handing out statin drugs like candy CAD is still the #1 cause of death each

year at roughly 630,000 deaths per year. We have the highest rate of cardiac disease in the entire world despite all

of the most so called state of the art drugs…in fact statin drugs have led some 200,000 people to develop

irreversible muscle wasting syndrome which is always fatal; and statins have also been linked to advanced liver

and kidney disease.


In reality the solution to this problem of oxidized LDL is very simple if you understand plant based biochemistry.

Dr. Pritikin thought the reversal of plaque and CAD was due to the very low intake of fats in the diet he created. In

fact that had little to do with anything, it was the antioxidants from a huge assortment of fruits and vegetables

which prevented LDL from oxidizing in the coronary arteries and thus stopped inflammation and the whole above

described process of oxidized LDL leading to CAD.

The problem with the Pritikin program is it is so very restrictive in calories that most folks simply cannot make a

lifelong commitment to it. We also now know about antioxidants in the form of nutraceutical plant based

supplements 1000’s of times more powerful then eating the fruits and veggies on the Pritikin diet.

We should all breathe easier knowing that when it comes to INHIBITING LDL oxidation we can now stop it cold with

natural biochemicals such as UBIQUINOL CoQ10…. With the exception of Alpha Lipoic Acid and the active

biochemical in Pomegranate (Proanthocyandids, and Polyphenols) nothing is effective as CoQ10, we can actually

now improve the inhibition of oxidized LDL cholesterol by 130%… far greater protection then the Pritikin diet.17

Yet we can go even far greater in reversing CAD by taking Nutraceutical quality Omega 3 oils every day. Omega 3

fish oil, Krill oil and Green Lipid muscle oil are extraordinarily powerful inhibitors of inflammation. The above are

such powerful High Density Lipids the good HDL’s, they can virtually assure that hard LDL cannot clump together,

in fact Eskimos and the arctic circle indigenous peoples account for five million people. They eat huge amounts of

cholesterol from seal blubber and whale blubber yet we have never found even one upon autopsy who had CAD.

Think about that, although they eat a diet 80% pure cholesterol they are completely protected by the 18% of their

diet which is cold water fish oil in the form of wild salmon.18-22

Stacking Powerful Antioxidants… The Sosna Protocol to cure advanced CAD

I have created a unique program by stacking the most powerfully effective antioxidants to reverse CAD for even

the most advanced CAD patient. Besides the above mentioned powerful antioxidants the stacking of nutraceutical

antioxidants also includes:

SAMe, Folic acid, isoflavones, Epigallate-Catchen-3 Galate, Resveratrol, Tocotrienols, Vit. E, Lutein, Lycopenes,

Ascorbyl Palmitate, Gingerols, Silymarin, Bromelain, Calcium D-Glucarate, Punicalagins, Hesperidin, Canthaxathin

and several others if need be. All of these super antioxidants are found only in the bio-diversity of plant based

molecular biochemistry in nature and in scientifically fresh cold pressed ocean based omega 3 fatty acids.

President Clinton is receiving with stellar results a similar protocol to mine…He will not need any more balloon

angioplasty or any other invasive treatments again so long as he stays on this treatment protocol for life.

In addition we have discovered plant extracted sterols can lower LDL by 38% in a very unique manner. They trick

the production of harmful LDL from entering the blood stream and instead send them a signal to enter the large

intestines where they are excreted via normal bowel movements.

In conclusion we have had for a long time the most effective all natural treatment protocol for reversing

cardiovascular disease. All the natural biochemicals I have mentioned are derived from plants, fruits, and marine

life, extracted and highly concentrated by a leading biotechnology company which is ISO 9001 and ISO 17025

While one may be tempted with this information to do it yourself without expert guidance, I strongly urge you to

consider the following. Eighty percent of all stores bought cold water fish oil sold as omega 3 HDL is already rancid

when purchased! Rancid oils have enormous amounts of free radical oxidants which cause CAD.  Unless you are

positive you are obtaining your nutraceutical supplements from a true ISO certified biotechnology laboratory be

very careful. The quality and purity of store the supplements will be no more than 20% pure due to their poor

quality extraction methodology, the other 80% may include large amounts of biological fragments, fillers, and

environmental toxins to the point where one is actually consuming enormous amounts of free radical oxidants

which seriously damage the heart, and other organs! Why? Because market competition is so fierce in the

supplement industry over 90% of the drug store and health store brands buy their raw materials from China; where

raw materials for making supplements are extremely inexpensive. The problem is China is the most polluted

industrial toxic country and raw organic material from China to make supplements will have high levels of toxins.

Any supplements made in the USA but sourced from China may be highly toxic. They will never be made by ISO

9001 ISO 17025 biotechnology companies; you simply cannot find this highest quality in health food stores and if

they claim they carry such a high standard ask the manager for a certified copy of ISO 9001 ISO 17025 for the item

you desire to purchase. They cannot produce the above mentioned certifications because there are only several

biotechnology companies worldwide, that have both ISO certifications and they only sell to doctors, dentists,

naturopathic doctors and nutritionists with a PhD.

Peer Reviewed research and footnotes.

1. Roberts CK, Chen AK Bernard JR Effects of short term diet and exercise intervention in youth on atherosclerotic

disease risk factors. Atherosclerosis. 2007 mar; 191 (1) : 98-106

2. Roberts CK, won D, pruthi S, et al. Effects of short term diet and exercise intervention on oxidative stress,

inflammation, MM-9, and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl

Physiol. 2006 may; 100(5): 1657-65.

3. Roberts CK, Vaziri ND, Bernard RJ. Effects of diet and exercise intervention on blood pressure, insulin,

oxidative stress, and nitric oxide availability. Circulation. 2002 Nov 12;106(20):2530-2.

4. Anderson JW, Konz EC, Jenkins DJ. Health advantages and disadvantages of weight-reducing diets: a computer

analysis and critical review. J Am Coll Nutr. 2000 oct;19(5):587-90

5. Henriksen T Mahoney EM Steinberg D. Enhanced macrophage degradation of low density lipoproteins previously

incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

Proc Natl acad Sci USA. 1981 Oct;78(10):6499-503.

6. Hessler JR, morel DW, Lewis LJ, Chisolm GM. Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

Arteriosclerosis. 1983 May;3(3):215-22.

7. Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential

role in recruitment and retention of monocyte/macrophages during athero-genesis. Proc Natl Acad Sci USA.

1987 may;84(9):2995-8.

8. Ross R. Atherosclerosis—an inflammatory disease. N Engl J med. 1999 Jan 14;340(2):115-26.

9. Ross R. The pathogenesis of atherosclerosis-an update. N Engl J Med. 1986 Feb 20;314(8):488-500.

10. Yla-herttuala S, Palinski W Rosenfeld ME, et al. Evidence for the presence of oxidatively modified LDL in

atherosclerotic lesions of rabbit and man. J Clin invest. 1989 Oct;84(4):1086-95.

11. Steinberg d, Carew TE, khoo JC, witztum JL. Beyond cholesterol. Modifications of LDL that increase its

atherogenicity. N Engl J Med. 1989 Apr 6,320(14):915-24.

12. Berliner JA, navab m, Fogelman AM, et al. Atherosclerosis: basic mechanisms. Oxidation. Inflammation, and

genetics. Circulation. 1995 May 1;91(9):2488-96.

13. Suits AG, Chait A Aviram M, Heinke JW. Phagocytosis of aggregated lipoprotein receptor-dependent foam cell

formation. Proc Natl acad sci USA. 1989 Apr;86(8):2713-7.

14. Zhang WZ, Vernardos K Finch S, kaye DM. detrimental effect of oxidized LDL on endothelial arginine

metabolism and transportation. Int J Biochem Cell Biol. 2008;40(5):920-8

15. Faloon W. A lethal misconception of epidemic proportion. Life Extension. 2007 May; 13(5):7-14.

Danesh j, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major