Anti-Aging Answer for Men’s good health using Testosterone

Larry Sosna N.D. PhD HHP

Men are exclusively simple when it comes to a man’s critical hormones, which build a man up

and cause regeneration of muscles bones and some extremely crucial brain function. These all

lie in a man’s ability to make youthful blood levels of Testosterone. Always remember it is

testosterone that keeps all muscles in the body at their normal size and ability to function in a

youthful manner Testosterone keeps men vigorously healthy.

A man produces testosterone by the posterior pituitary’s release of LH which then triggers the

release of HCG which further instructs a man’s testicles to make testosterone. The other super

powerful regenerator of all cells tissues and organs is HGH human growth hormone. These two

hormones kept at youthful blood levels will stop a man from early stage Andropause. All

medical research scientists agree low testosterone is a main cause of male Andropause….The

inability for a man to make youthful blood levels of testosterone. Interesting that the virtually

all male board of American medicine the AMA does not recognize the validity of male

Andropause….. Ego and false pride changes nothing, when you can no longer make the 2 critical

male hormones at youthful blood levels, the reality is just like female menopause, men

change….and that change leads to old age and early death.

Testosterone is made in great abundance in young men age 13 to 30. Testosterone is the

combination on the molecular level of Cholesterol, the B vitamins and Oxygen.

However as we age past age 35 there is a large drop off in about 70% of male production of

testosterone according to the national Institute for Health (NHI) If this drop in production of

testosterone is too severe and happens too quickly, the heart being a muscle can quickly get too small and

not be able to meet cardiac blood stroke volume….the amount of blood needed by the entire

body per beat of your heart.

This can lead to a very sudden electrical storm within the heart

muscle causing severe arrhythmias’ followed by death according to the Harvard ten year

medical study on the human heart…. And we are not talking about a few men dying this way

per year, the CDC estimates nearly 170,000 men die each year caused by the above mentioned

causes.

All men can avoid the above described horror by taking swift action and getting a blood test

done to see what your testosterone levels are….forget about the reference range we look at

what is the OPTIMAL range for testosterone at youthful levels I keep mine at 800 to 950. Most

men over 45 will come in with blood levels of roughly 250 to 475, I and a team of scientist/doctors

consider that range to be dangerously low.

So if you have symptoms of :

1. Low Energy, sudden fat built up around your waistline over the last 2 years, sleep
2. Poor sleep
3. Inability to concentrate
4. Lower sex drive
5. And irritability….you are looking at Low Testosterone
6. If you have severe loss of testosterone you could lose hair, have muscle tears, and even

bone fractures…even if you are in your late 40’s and 50’s

Once we restore you to youthful levels of testosterone you will have these great

Benefits:

1. Decrease in body fat
2. Increased Muscle tone
3. Stronger muscles and bones
4. Improved mood
5. Higher sex drive
6. Improved sleep
7. Enhanced sense of well being
8. A stronger healthier heart
9. Increased stamina for work, play, and exercise
10. Greater Stamina

Several other important factors for men is to keep certain foods very high in your diet:

1. Pumpkin seeds, have a very high amount of Zinc which prevents prostate cancer and is a good

source of fiber

2. A zinc nutraceutical supplement is a must starting when a man is 25 years old
3. Almonds just 10 per day have for 50 years been associated with prevention of cancer of the Lymph

glands in men.

4. Acetyl- L Carnitine is found in very lean meat, try hard to eat organic meat from Whole foods.
5. If you use milk every morning with cereal please buy organic milk free of pesticides as regular milk

has enormous concentrations of Estrogen like substances in it which can make a man of young age

need testosterone…I have had several patients that were 27 and 28 years old that had testosterone

levels of a 70 year old due to the fact that they drank large amounts of regular milk daily.

Men doing these above recommendations will help the massive positive effects of testosterone and

good health for men.

Hormonal determinants of the severity of andropausal and depressive symptoms in middle-aged and elderly men with prediabetes.

Rabijewski M, Papierska L, Kuczerowski R, Piątkiewicz P.

Clin Interv Aging. 2015 Aug 20;10:1381-91. doi: 10.2147/CIA.S88499. eCollection 2015.

Erectile dysfunction, loss of libido and low sexual frequency increase the risk of cardiovascular

disease in men with low testosterone.

Ho CH, Wu CC, Chen KC, Jaw FS, Yu HJ, Liu SP.

Aging Male. 2016 Jan 11:1-6. [Epub ahead of print]

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Risks associated with low Human Growth Hormone for Men and Women

                                          Dr. Larry Sosna N.D. PhD HHP

Men and women who suffer from low human growth hormone (HGH) can have extremely severe symptoms.

Please understand that the pituitary gland is called the master gland of the entire Endocrine System…that essentially means the pituitary is responsible one way or another for how all the hormones are produced and how they function.

The human body has a communication system called homeostasis which is designed to keep all structures and functions within the human body at a so called normal range. Average normal temperature is 98.6 and blood pressure is well functioning at 120/80. There is according to the laws of homeostasis a normal for virtually everything in the human body.

There is a key involved in all this homeostasis. Obviously my toe is not as important as my heart or brain so in moments of stress ones tow may forego for a few minutes some blood flow while the heart is instructed to beat somewhere between 60 and 98 beats per min.

The key most important key in homeostasis is called the Adrenal, Hypothalamic, Pituitary Axis.

Many scientists will argue this is the control panel for the entire human body just the way an advanced jet plane has a sophisticated control panel and if it does not work correctly we might not safely get back to the ground.

Think of all this as you’re potential for superb excellent health as scientists have learned much about helping out the human control panel to work and function in a greatly improved manner.

Conversely, if the anterior pituitary is not making enough (HGH) human growth hormone a massive aspect of the human control panel is malfunctioning.

We know this by a set of symptoms and by seeing a blood count of IGF-1 too low.

Sometimes, symptoms are very pronounced but IGF-1 levels seem ok….Research doctors in the field virtually always agree that vast symptoms trump a number on a test.

HGH is so important it takes up one half of the entire pituitary gland and in that half the anterior section HGH and only HGH is made. Established high level of Importance.

Functions:

Proper levels of HGH allow for all cell repair and regeneration.

It does this by activating and instructing each type of tissue like heart tissue

Or lung tissue or skin tissue to find the tissue growth factor in each type of tissue

And HGH tells all of those super important tissue growth factors to get ready and gear up to repair and regenerate.

When we get older HGH falls and once it falls too low and that can even happen to a 35 year old

If they have had way too much stress and illness in life.

So it is a great THREAT to the body not to able to complete tissue repair and regeneration.

In time scientists know that can lead to smaller organs and age related diseases of all kinds.

There are special symptoms and threats from Low HGH that apply to Women:

Women are very special in that they can carry on and bring forth new children. To be capable of doing such a daunting task nature gave women under her skin 2 layers of fat tissue. Fat is a living tissue. Nature gave women this extra layer that men do not have to preserve our species the human family…for in times when food is scarce and a woman is with child she may have to give up the entire second layer which surrounds the entire body just to give the baby a chance of living.

When women become low in HGH they are usually at an age when their other hormones are getting too low as well. Low HGH in women causes the second layer of fat to thicken and that is not good for the cardiovascular system, blood pressure and can even start the beginning of what is known as fatty liver disease.

Unfortunately, women lose progesterone 12 years before she starts to lose estrogen. A women losing both progesterone, and is say 40 and also losing estrogen is in all likelihood low in HGH and when proven so she is at much greater risk from cardiac issues then a man.

After menopause it has been well documented that women are at a higher rate for both heart attacks and strokes, one of the reasons why is low HGH which is highly protective of the heart and brain when HGH is optimized to more youthful levels by the addition of HGH therapy. One can avail themselves of much greater cardiovascular protection.

It may sound like a small thing but low HGH in women can be responsible for thinning hair, dry hair and dry skin. Also with low HGH women cannot grow longer nails….again to most women that is not a joke or a small matter.

Originally women in the course of life made a bit more HGH from their pituitary gland but even perimenopause will create a homeostatic signal to make less HGH and thus women start to lose collagen and elastin so needed for healthy arteries as well as joint function.

Another aspect, is when women have low HGH, there is a decline in L-Dopamine. This neurotransmitter is vital for the pleasure response, including the ability to enjoy sexual activity. Why? Because L-Dopamine levels need to be high enough to make Oxytocin, which most definitely is needed for mood elevation and sexual desire.

Low HGH in women means they are subject to early bone loss as it is HGH that creates new bone cells, osteoporosis is a terrible burden, it is very painful and once it starts the only thing that can change it course fully is to restore HGH levels, back to a more youthful level. When it is has gone too far and HGH has been too low for too long that is when women get that hump curved shape to the upper spine. Women this is 100% avoidable with restored youthful levels of HGH but one must start at the correct time.

Women, who start just before perimenopause say at age 36, are so different looking than their counterparts who have not done this. They have wonderful muscle tonality, their skin looks youthful, and there is an undefinable ineffable golden glow that shows in their face…after all these years I can almost always spot women who took action and availed herself of HGH before premature aging.

                         Are We on the Verge of Curing Cancer?

I have always viewed cancer as a radical illness that needs a wide range of different kinds of treatments. This excellent article featured on CNN is just what I have been talking about using Immune-Therapy from your own body to kill off cancer tumors before they overwhelm the body.       Larry Sosna N.D. PhD HHP

Source: CNN

Fighting cancer by targeting its ‘Achilles’ heel’ 01:51

Story highlights

• Scientists have discovered possible new ways to attack core mutations in a patient’s cancer cells
• There are several limitations, including cost and the speed at which treatments could be developed

(CNN)A new breakthrough in cancer research could lead to a novel form of cancer treatment — one that is highly specialized for each patient.

Researchers discovered that even though cancer cells mutate wildly within a person’s body, the cancer cells within each patient also have common mutations — ones that could be isolated and fought off by certain immune cells.

Think of it this way: A patient’s cancer cells all start off with the same tree trunk, but then grow different kinds of branches. The new research shows certain immune cells can “chop the tree at the trunk rather than just pruning the branches,” Dr. Sergio Quezada told CNN.

WHO urges cancer prevention 02:42

Quezada, from the University College London’s Cancer Institute, co-authored the study, which was published Thursday by Science magazine.

For years, one of the biggest obstacles in fighting cancer has been the fact that a tumor’s cancer cells are not all the same.

“The tumor is an evolving mass. Mutations change here and there. Mutations in one area of the tumor are usually different from mutations in other parts of the tumors,” Quezada said.

Read: These dogs can sniff out cancer better than some tests

In a statement to Cancer Research UK, he likened the fight against cancer to police chasing a wide array of criminals.

“The body’s immune system acts as the police trying to tackle cancer, the criminals. Genetically diverse tumours are like a gang of hoodlums involved in different crimes — from robbery to smuggling. And the immune system struggles to keep on top of the cancer — just as it’s difficult for police when there’s so much going on,” he said.

“Our research shows that instead of aimlessly chasing crimes in different neighborhoods, we can give the police the information they need to get to the kingpin at the root of all organized crime — or the weak spot in a patient’s tumor — to wipe out the problem for good.”

What this means for treatment

Quezada told CNN this discovery could lead to two kinds of treatment:

1) Making customized vaccines to target the core mutations in each patient.

2) Identifying which immune cells, or T-cells, can fight off those core mutations, then multiplying those T-cells in a lab.

Quezada said the customized vaccines would be “the ultimate personalized form of therapy.”

Billionaire behind Cancer Moonshot 2020 02:49

“This would mean basically taking a cancer tumor, finding the trunk, and then designing a vaccine (to) inject in the patent,” he said.

“The second approach is to ‘fish’ these cells — T-cells — that recognize the trunk, expand them outside the patient” and inject them in the body.

Quezada said no human trials have started using either approach in light of the study, but said he hopes trials will begin within five years.

Read: Blindsided by cancer? 5 things to do

The limitations

But the discovery doesn’t mean all cancer patients will be cured soon. The potential for new treatment also has several limitations.

First is “the speed at which you can generate personalized therapy,” Quezada said. “Some cancers go really fast.”

Pharmaceutical CEO speaks about $1 cancer drug 03:32

Developing a customized vaccine, for example, could take more time than a cancer patient has.

Second, it would be expensive. Quezada said he doesn’t have an estimate on how much either type of treatment would cost, but given the highly customized nature of each, it could be extremely expensive.

“That’s going to be an important point of this discussion,” he said.

Finally, such treatments would likely work better for some types of cancer than others. Quezada said he believes lung cancer and melanoma would be the most likely to respond well to such treatment.

Read: Why cancer drugs worth $3B are wasted

A massive collaboration

A team of 36 international researchers worked on the study, which included scientists from the London, the United States, Denmark and Germany. The study was funded by Cancer Research UK and the Rosetrees Trust.

“It’s the most amazing collaboration I’ve ever worked on, Quezada said. “It’s been an amazing roller coaster.”

The next roller coaster will be determining when patients could receive the treatments — and learning how well they might work.

CNN’s Dominique Heckels contributed to this report.

Healing Injured Spinal Discs even ones which have Herniated

Larry Sosna N.D. PhD HHP

There have literally been several hundred peer reviewed research articles on how Human Growth Hormone works to regenerate all cells, tissues and organs, in the human body. The process is a very elegant one which gives rise to a much greater understanding of how the human body heals itself after injuries. In general this is how the HGH system of bodily healing and repair works.

If a person has youthful blood levels of HGH any injury anywhere sends out signals through the biofeedback communication loops to send HGH to the liver were IGF-1 is made. IGF-1 signals all the cells, tissues and organs of the body to release its specific Embryonic Tissue Growth Factors (ETGF.) The ETGF mobilize to do protein synthesis to the point where the tissues build up until repair is complete. Let’s look at a small example and then we can look at something which almost everyone needs repair and healing of…that being the discs of the spine… as many millions of people have hurt their backs…I have heard estimates can go as high as 3 out of 4 people in their life time have had painful back problems. First, allow me to get back to the small example of HGH in the healing process.

You are cooking and using a sharp knife to cut vegetables, time is of the essence and you cut faster then suddenly you go ouch! I cut my finger. You quickly clean the wound and then you notice it is a real cut but not down to the bone. In this case, it is called healing by first Intension, which means you will not need stitches and there will be a very little scar that with enough time will fade away completely. In this and all other cases what proceeds is exactly what I described above… Please notice how the very youthful heal from a cut finger much faster than a person 50 or 60 this is because at age 50 most folks are making roughly 70% less HGH than a person 18 years old. BUT, and I have experienced this for myself many times as have many other folks 40 and up who take shots of HGH to get  back to youthful blood levels of HGH… my finger cut will heal very quickly. I, and many of my clients on HGH report the very same thing…cuts heal about twice as fast as a person age 40 and up who does not take injections of HGH. The reason for this small example is I cut my finger with a very sharp knife I was making dinner about 4 days ago… when a friend called out to me  I turned my head to look at her and the next thing I knew blood was all over my kitchen floor. I have personally been on supplemental injections of HGH for 23 years and in just 4 days a fairly deep cut is almost completely gone.

Let’s look at the HGH healing formulation again. Youthful blood levels of HGH = a speedy regeneration of all types of wounds including rebuilding new discs which have been wounded through herniation of the disc. Once again, please allow me to illustrate how to regenerate a new healed disc from an old injured one.

What are the discs subcomponents? In other words what is the disc made of? Problematically, it is made of Fibrocartilage. Why do I say it is problematic? Because, Cartilage has no vascularity and thus no blood supply to quickly bring in the embryonic Mesenchyme Tissue Growth Factor and HGH which does regenerate Cartilage, BUT very slowly. Why? Because without a blood supply, Cartilage must get all nutrients and healing Growth Factors plus IGF-1 through the very slow process of osmosis. How did I learn to make the process go faster? First, by heating the affected disc with hot packs for 25 min each day, This gets more blood into the affected area .Next I showed folks how repeated soft movement 5 to 6 times a day makes the process of osmosis go much faster. Why? Because correct movement is like a pump…pumping all the healing agents mentioned above through the disc. Thus if you are one of the many millions who have injured discs and you want to regenerate them as I have for myself one will need to avail themselves of both HGH and Embryonic Mesenchyme Growth Factor which you can obtain right here at the SOSNA ANTI-AGING Rejuvenation Center…where we not only deeply care for all of our family of clients…BUT we also engage in the most cutting edge regenerative protocols… which is why we justly say about competition…They may be catching on but they are NOT catching up. It is our unyielding commitment to ourselves and to you are family of clients we care for.

Peer Reviewed References

·         Evaluation of patient satisfaction with second intention healing versus primary surgical closure

• Journal of the American Academy of Dermatology,Volume 73, Issue 5, November 2015, Pages 865-867.e1
• William G. Stebbins, Julia Gusev, H. William Higgins II, Andrew Nelson, Usha Govindarajulu, Victor Neel

Zone-specific integrated cartilage repair using a scaffold-free tissue engineered construct derived from allogenic synovial mesenchymal stem cells: Biomechanical and histological assessments.

Fujie H, Nansai R, Ando W, Shimomura K, Moriguchi Y, Hart DA, Nakamura N.

J Biomech. 2015 Oct 19. pii: S0021-9290(15)00563-1. doi: 10.1016/j.jbiomech.2015.10.015. [Epub ahead of print]

Journal of Biological Chemistry 2003, Oct,24 Shi-Wen X, Abraham D.J. Denton C, Black, CM.

Effect of Human Adipose Tissue Mesenchymal Stem Cells on the Regeneration of Ovine ArticularCartilage.

Zorzi AR, Amstalden EM, Plepis AM, Martins VC, Ferretti M, Antonioli E, Duarte AS, Luzo AC, Miranda JB.

Int J Mol Sci. 2015 Nov 9;16(11):26813-26831.

Synergistic effect of ascorbic acid and collagen addition on the increase in type 2 collagen accumulation incartilage-like MSC sheet.

Sato Y¹, Mera H^2,3, Takahashi D⁴, Majima T⁵, Iwasaki N⁴, Wakitani S⁶, Takagi M⁷.

Author information

• ¹Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Kita-ku, N13W8, Sapporo, 060-8628, Japan.
• ²School of Health and Sports Sciences, Mukogawa Women’s University, 6-46 Ikebiraki, Nishinomiya, Hyogo, 663-8558, Japan.
• ³Foundation for Biomedical Research and Innovation, International Medical Device Alliance, 1-6-5, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
• ⁴Department of Orthopaedic Surgery, Graduate School of Medicine, Hokkaido University, Kita-ku, N15W7, Sapporo, 060-8638, Japan.
• ⁵Department of Joint Replacement and Tissue Engineering, Graduate School of Medicine, Hokkaido University, Kita-ku, N15W7, Sapporo, 060-8638, Japan.
• ⁶Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 739-8553, Japan.
• ⁷Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Kita-ku, N13W8, Sapporo, 060-8628, Japan.

Mesenchymal stem cells: clinical applications and biological characterization

• Frank P Barry^,,
• Mary Murphy
• Osiris Therapeutics Inc., 2001 Aliceanna Street, Baltimore, MD 21231, USA

Received 22 September 2003, Revised 30 October 2003, Accepted 3 November 2003, Available online 24 January 2004

Volume 28, Issue 8, August 2000, Pages 875–884

Review

Mesenchymal stem cells: Biology and potential clinical uses

• Robert J. Deans^,,

Annemarie B. Moseley

By Dr. Larry Sosna N.D. PhD HHP

SOSNA LABORATORIES® 02/2015  Corvalen® Chews are an all natural D-ribose supplement clinically proven to help restore and replenish core energy. D-ribose is a natural pentose sugar that is designed for the support of cardiovascular health, fatigue, energy production, and mitochondrial function†. Corvalen® chewable tablets are great tasting with natural orange/vanilla flavoring sweetened with xylitol, and readily absorbed into the body. FUNCTIONS Corvalen® contains pure D-ribose, a safe and clinically researched ingredient that supports the natural way our bodies produce adenosine triphosphate (ATP), the energy currency of the cell. †Ribose is the vital structural backbone of critical cellular compounds called purines and pyrimidines. Our bodies must have an adequate supply of purines and pyrimidines to form major cellular constituents such as our genetic material (DNA and RNA), numerous cofactors, certain vitamins, and, importantly, adenosine triphosphate (ATP). Ribose is the starting point for the synthesis of these fundamental cellular compounds, and the availability of ribose determines the rate at which they can be made by our cells and tissues. D-ribose is a structural component of DNA, RNA, ATP, GTP, flavins (FAD, riboflavin) and other important nucleotides found in all living cells. Ribose is formed naturally via the pentose phosphate pathway. This pathway is slow and rate-limited in cardiac and skeletal muscle due to an inherently low concentration (lack of expression) of the enzymes, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. The product of this pathway is ribose-5-phosphate, which in turn is converted to 5-phosphoribosyl-1- pyrophosphate (PRPP), the primary driver in the synthesis and salvage of purine nucleotides. No other compound can be used by the body for this metabolic purpose. Purine nucleotides (ATP and its precursors) lost due to ischemia, hypoxia, or genetic predisposition are replaced via the purine nucleotide pathway. This pathway is rate limited by the availability of ribose in tissue. Administration of exogenous ribose bypasses the rate-limiting steps in the pentose phosphate pathway, resulting in a significant acceleration of PRPP. Renewed concentration of ATP is accompanied by an increased energy potential in the cell, also known as the “energy charge.” Cardiac and skeletal muscle functions (i.e. contraction, cell wall maintenance, relaxation, polarization of the cell membrane) each require a different, quantifiable energy charge to drive or provide allosteric regulation for each function. Restoration of cellular energy charge restores function consistent with the degree of energy charge restored. D-ribose is indicated for sports and fitness activities because it helps to reduce the loss of energy during stress and accelerate energy and tissue/muscle recovery†. Endurance athletes and strength training athletes may both benefit from the effects of supplemental D-ribose. Unless our hearts have an adequate supply of ribose, they simply cannot satisfy their astonishing energy demand. Our bodies make ribose naturally, but in times of stress the need is greater than our supply to satisfy the loss of energy from our cells. That is why supplementing with d-ribose can support proper heart function and helps maintain healthy stroke volume during and after high intensity exercise†. A study by Olman et al. in 2003 showed beneficial effects on diastolic function and quality of life in compromised patients after only 3 weeks of supplemental D-ribose. Although D-ribose is a five-carbon monosaccharide, it does not raise blood sugar. Corvalen® D-ribose is non-GMO. D-ribose is rapidly and readily (~95%) absorbed with peak blood levels found within 30 – 45 minutes. Ribose not taken up by the cell is excreted unchanged in the urine. Corvalen® D-ribose is GRAS (generally recognized as safe), a determination that results only after considerable toxicology studies are performed and an expensive and time consuming FDA process is completed.